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Image Search Results
Journal: Frontiers in Pharmacology
Article Title: A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies
doi: 10.3389/fphar.2021.639840
Figure Lengend Snippet: Potential anticancer effects and related mechanisms of action of naringin based on in vitro studies.
Article Snippet: Sarcoma (osteosarcoma) ,
Techniques: In Vitro, Control, Activity Assay, Inhibition, Protein-Protein interactions, Transduction, Purification, Mass Spectrometry, Migration, High Performance Liquid Chromatography
Journal: Frontiers in Pharmacology
Article Title: A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies
doi: 10.3389/fphar.2021.639840
Figure Lengend Snippet: Potential anticancer effects and related mechanisms of action of naringin based on in vivo studies.
Article Snippet: Sarcoma (osteosarcoma) ,
Techniques: In Vivo, Animal Model, Control, Purification, Liquid Chromatography
Journal: Journal of Translational Medicine
Article Title: SLC38A5 suppresses ferroptosis through glutamine-mediated activation of the PI3K/AKT/mTOR signaling in osteosarcoma
doi: 10.1186/s12967-024-05803-6
Figure Lengend Snippet: SLC38A5 is up-regulated in osteosarcoma and associated with a poor prognosis. ( A ) The expression patterns of SLC38A5 across various tumors in the TCGA dataset based on the TIMER database. ( B ) The relative mRNA level of SLC38A5 in tumor ( n = 12) and adjacent normal tissues ( n = 12) based on clinical samples. ( C ) The protein level of SLC38A5 was assessed in osteosarcoma tissues and adjacent normal counterparts using western blot. ( D ) The quantitative analysis of the western blot result. ( E-F ) The protein level of SLC38A5 in human osteoblastic cell (hFOB1.19) and osteosarcoma cell lines (HOS, Saos-2, MG63, U2OS, 143B). ( G ) The mRNA level of SLC38A5 in different cell lines. (H-I) Kaplan–Meier survival analysis of SLC38A5 in osteosarcoma based on the TARGET database ( n = 86) and GSE21257 dataset ( n = 53). The median value of SLC38A5 expression is the cut-off for high and low expression. Results from three independent experiments are summarized in a histogram format. * P < 0.05, ** P < 0.01, *** P < 0.001
Article Snippet: The human osteosarcoma cell lines HOS, Saos-2 and
Techniques: Expressing, Western Blot
Journal: International Journal of Biological Sciences
Article Title: Vitamin K 2 Ameliorates Damage of Blood Vessels by Glucocorticoid: a Potential Mechanism for Its Protective Effects in Glucocorticoid-induced Osteonecrosis of the Femoral Head in a Rat Model
doi: 10.7150/ijbs.15248
Figure Lengend Snippet: VEGF expression analysis in EAhy926 and MG63. A. Western blotting analysis of total cell lysates in EAhy926, β-actin was used as the loading control. B. VEGF mRNA expression in EAhy926 treated with or without DEX and VK 2 , each condition was performed in triplicate (* indicated P < 0.05; ** indicated P < 0.01). C. Western blotting analysis of total cell lysates in MG63. β-actin was used as the loading control. D. VEGF mRNA expression in MG63 cells treated with or without DEX and VK 2 , each condition was performed in triplicate (* indicated P < 0.05; ** indicated P < 0.01).
Article Snippet: The human endothelial cell line EAhy926 and the
Techniques: Expressing, Western Blot, Control
Journal: International Journal of Biological Sciences
Article Title: Vitamin K 2 Ameliorates Damage of Blood Vessels by Glucocorticoid: a Potential Mechanism for Its Protective Effects in Glucocorticoid-induced Osteonecrosis of the Femoral Head in a Rat Model
doi: 10.7150/ijbs.15248
Figure Lengend Snippet: Effect of DEX and VK 2 on angiogenic factors in EAhy926 and MG63. (A-E) Quantitative RT-PCR analysis of KDR, Flt, vWF, CD31 and PDGF-B in EAhy926. (F,G) TGF-β and BMP-2 mRNA expression in MG63. (Each condition was performed in triplicate, * indicated P < 0.05, ** indicated P < 0.01).
Article Snippet: The human endothelial cell line EAhy926 and the
Techniques: Quantitative RT-PCR, Expressing